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|Section2= |Section3= }} Callystatin A is a polyketide natural product from the leptomycin family of antibiotics. It was first isolated in 1997 from the marine sponge ''Callyspongia truncata'' which was collected from the Goto Islands in the Nagasaki Prefecture of Japan by the Kobayashi group. Since then its absolute configuration has been elucidated and callystatin A was discovered to have anti-fungal and anti-tumor activities with extreme potency against the human epidermoid carcinoma KB cells (IG50 = 10 pg/ml) and the mouse lymphocytic leukemia Ll210 cells (IG50 = 20 pg/ml). ==Isolation From Marine Organisms== Kobayashi and associates isolated callystatin A in 1997 from the marine sponge ''Callyspongia truncata'' using acetone as the extracting solvent.〔 This marine sponge was discovered near the Goto Islands of the Nagasaki Prefecture in Japan. Kobayashi also reported the isolation of callystatin A from another marine sponge ''Stelletta sp.'' and an unidentified marine tunicate, both of which were collected at the same site as ''Callyspongia truncata''.〔 It is possible that there is a symbiotic relationship among these microorganisms which can explain their biosynthesis of callystatin A.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Callystatin A」の詳細全文を読む スポンサード リンク
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